Jinguo Wang

2015-Present  Associate Director of HLA lab, UHN
2015-2014     Assistant Director of HLA lab, The University of Chicago
2012-2014      Fellow, Calgary Laboratory Services, Alberta Health Region
2006-2012      Post-doc fellow University of Calgary
1999-2006      Ph.D Memorial University of Newfoundland    

Research Synopsis

Transplantation remains to be one of the ultimate life-saving treatments for patients suffering from end stage organ/tissue failures. Although a lot of progress has been made to increase the success rate of this treatment, human leukoantigen (HLA) and its associated immune responses (host versus graft and graft versus host) remain to be one of the major obstacles in the setting of allo-transplantation. Two major roles of HLA lab are to perform HLA typing and to identify the specificities of anti-HLA antibody responses. Various platforms are currently being used to achieve these two objectives. My interest is to develop more clinical applicable assays to improvise, enhance and supplement the current assays and to look into the clinical outcomes based on the interpretation of various HLA lab testing data. Long term goal is to study the mechanisms of immune tolerance and aiming to develop a strategy to induce allo-HLA tolerance in the host of transplant recipients.    

Recent Publications

Brown NK, Kheradmand T, Wang J, Marino SR.(2016) Identification and characterization of novel HLA alleles: Utility of next-generation sequencing methods. Hum Immunol. 77(4):313-6

Clemente-Casares X, Blanco J, Ambalavanan P, Yamanouchi J, Singha S, Fandos C, Tsai S, Wang J, Garabatos N, Izquierdo C, Agrawal S, Keough MB, Yong VW, James E, Moore A, Yang Y, Stratmann T, Serra P, Santamaria P. (2016)  Expanding antigen-specific regulatory networks to treat autoimmunity. Nature. 530(7591):434-40.

Wang J, Kostur C, Stamm L, Khan F and Berka N.  (2015) Identification of the novel allele, HLA-B*27:131. Tissue Antigens. 85(2):142-4.

Wang J, Nanjundappa RH, Shameli A, Clemente-Casares X, Yamanouchi J, Elliott JF, Slattery R, Serra P, Santamaria P. (2014)  The cross-priming capacity and direct presentation potential of an autoantigen are separable and inversely related properties. J Immunol.193(7):3296-307.

Alkemade GM, Clemente-Casares X, Yu Z, Xu BY, Wang J, Tsai S, Wright JR Jr, Roep BO, Santamaria P. (2013) Local autoantigen expression as essential gatekeeper of memory T-cell recruitment to islet grafts in diabetic hosts.  Diabetes. 62(3):905-11.

Wang J, Tsai S, Han B, Tailor P, and Santamaria P. (2012) Autoantigen recognition is required for recruitment of IGRP206-214 reactive CD8+ T cells but is dispensable for tolerance.  J. Immuol. 189(6):2975-84.

Shameli A, Clemente-Casares X, Wang J and Santamaria P. (2011) Development of memory-like autoregulatory CD8+ T cells is CD4+ T cell dependent.  J. Immuol. 187(6):2859-66.

Wang J, Tsai S, Shameli A, Yamanouchi J, Alkemade G and Santamaria P. (2010) Retention and accumulation of CD8+ T-cells at a site of autoimmune inflammation is strictly antigen-dependent.  Proc Natl Acad Sci U S A. May 18;107(20):9317-22.

Tsai S, Shameli A, Yamanouchi J, Clemente-Casares X, Wang J, Serra P, Yang Y, Medarova Z, Moore A and Santamaria P. (2010) Reversal of autoimmunity by boosting memory-like autoregulatory T-cells.  Immunity 32(4):568-80.

Wang J, Wicker LS and Santamaria P. (2009) IL-2 and its high-affinity receptor: genetic control of immunoregulation and autoimmunity.  Semin Immunol. 21(6):363-371.

Guy CS, Wang J and Michalak TI. (2009) Hepadnaviral infection augments hepatocyte cytotoxicity mediated by both CD95 ligand and perforin pathways.  Liver Int. 30(3):396-405.

Tailor P, Tsai S, Shameli A, Serra P, Wang J, Robbins S, Nagata M, Szymczak-Workman AL, Vignali DA and Santamaria P. (2008) The proline-rich sequence of CD3epsilon as an amplifier of low-avidity TCR signaling.  J. Immuol. 181(1):243-55.