LMP200H1 – Pathobiology of the Cell
Enrolment is limited to students in the Pathobiology Specialist program.
Course description
This course builds on concepts in cellular pathobiology to develop an advanced understanding of the function and dynamics of the cell in the context of health and disease.
We cover concepts in cell injury, cell adaptation, migration, cell stress, cell survival, cell death, oxidative stress, endocytosis, ion homeostasis, protein folding, and their implications for disease.
By the end of the course, you should have a strong foundation in concepts in cellular pathobiology. You will be well prepared for 300-level LMP courses.
Course coordinator
Office address: 1 King’s College Circle, MSB 6314
Office address: 1 King’s College Circle, MSB 6275
Teaching Assistant
Kelly Liu
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Term |
Winter 2025 |
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Lecture time |
Friday 3 - 5 pm |
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Tutorial time |
Tuesday 2 - 3 pm |
|
Office hours |
By appointment |
Course details
- Hours: 24L/12T
- Prerequisite information: Enrolment is limited to students in the Pathobiology Specialist Program.
- Prerequisite: BIO230H1, PSL300H1
- Exclusions: LMP340H1
- Recommended preparation: BCH210H1
- Credit value: 0.5
- Distribution requirements: Science
- Breadth requirement: Living Things and Their Environment (4)
- Enrolment limits: 35 students
Student evaluation
Midterm exam: 35%
Assignment (due April 4, 2025): 30%
Final exam: 35%
Late submissions will incur a 5% penalty per day late.
See information on Academic Integrity
Schedule
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Date |
Title |
Instructor |
|---|---|---|
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January 10, 2025 |
Mechanisms of cell injury |
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January 17, 2025 |
Cell adaptation and cell death |
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January 24, 2025 |
Oxidative stress, ER stress and defenses |
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January 31, 2025 |
Calcium homeostasis/ signaling/ metabolism |
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February 7, 2025 |
Ion channels/pumps |
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February 14, 2025 |
Iron homeostasis/ metabolism and associated diseases |
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February 21, 2025 |
Reading Week - no class |
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February 28, 2025 |
Midterm (2 hours) |
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March 7, 2025 |
Transport through the membrane and exploitation by pathogens |
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March 14, 2025 |
Cytoskeleton and its role in the lifecycle of pathogens and neurodegenerative diseases |
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March 21, 2025 |
Protein misfolding, trafficking and proteinopathies |
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March 28, 2025 |
Protein degradation and associated diseases |
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April 4, 2025 |
Cell signaling and cancer |
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April 9 - 30, 2025 |
Final exam period |
Tutorials
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Date |
Topic |
Instructor |
|---|---|---|
|
January 7, 2025 |
Pathobiology. What and How? |
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January 14, 2025 |
Histology in a nutshell |
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January 21, 2025 |
Assignment discussion |
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January 28, 2025 |
Lecture material review and Q&A session |
Kelly Liu |
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February 4, 2025 |
Structure-function of ion channel and pumps |
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February 11, 2025 |
Molecular and cellular mechanisms of chronic hepatitis induced liver cancer HCC |
Kelly Liu |
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February 18, 2025 |
Reading break - no tutorial |
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February 25, 2025 |
Midterm exam material review and Q&A session |
Kelly Liu |
|
March 4, 2025 |
Critiquing research papers |
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March 11, 2025 |
Paper discussion: viral entry |
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March 18, 2025 |
Lecture material review and Q&A session |
Kelly Liu |
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March 25, 2025 |
Paper discussion: ubiquitin |
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April 1, 2025 |
Final exam material review and Q&A session |
Kelly Liu |
Recommended readings or text book
Molecular Biology of the Cell (6th Ed.). Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts and Peter Walter.