LMP460H1 – Pathobiology of the Cardiovascular System

Course description

This course covers the pathobiology of the heart and blood vessels.

The emphasis is on the underlying cell biology of processes such as:

Vascular Malformations: congenital and acquired
Atherosclerosis: Pathogenesis, Inflammation, Advanced Complications, Animal Models
Regenerative Medicine in the Cardiovascular System
Wearable monitoring of Cardiovascular Disease

Office address: 661 University Ave, MaRS II, 14th floor, Rm 1432
michelle.bendeck@utoronto.ca

Mary-Jo Hatem

Term	Winter 2025
Class time	Tuesday 10 am - 12 pm
Office hours	Contact TA or Course Coordinators

Hours: 24L
Prerequisite: (PSL300H1, PSL301H1) / PSL302Y1.Life sciences students who do not have all of the required prerequisites are encouraged to contact the academic unit to seek a waiver.
Corequisites: None
Exclusions: LMP406H1
Recommended preparation: None
Credit value: 0.5
Breadth requirement: Living Things and Their Environment (4)
Enrolment limits: 30 students

Midterm test: 40%

Final exam: 60%

Lecture topics are subject to change. We will list finalized lecture topics in the official syllabus.

Date	Topic
January 7, 2025	Vascular and Cardiac Structure and Function Introduction to atherosclerosis
January 14, 2025	Animal models of atherosclerosis
January 21, 2025	Inflammatory Mechanisms of Atherosclerosis
January 28, 2025	Thrombosis and Adhesion Molecules
February 4, 2025	Practice Questions and Review
February 11, 2025	Midterm
February 25, 2025	Vascular Development
March 4, 2025	Vascular Malformations
March 11, 2025	Calcification and Extracellular Matrix
March 25, 2025	MicroRNA regulation in atherosclerosis
April 1, 2025	Wearable Devices for Hemodynamic Remodeling