LMP310H1 – Fundamentals of Pathobiology
Course description
Enrolment is limited to students in the Pathobiology specialist program.
This course covers the major molecular mechanisms that impact human health and disease.
It is divided into three blocks that focus on the fundamentals of pathobiology in:
- cancer;
- cardiovascular diseases; and
- infection.
It is intended to introduce the cellular and molecular concepts of health and disease that will be explored with more depth in fourth-year LMP courses.
Course coordinators
Office address: UHN, 101 College St, MaRS, Room 3-306
myron.cybulsky@utoronto.ca
Office address: Sinai Health, 600 University Ave, Room 11C-310
felix.leung@sinaihealth.ca
Office address: UHN, 101 College St, MaRS Room 3-302
s.macparland@utoronto.ca
Teaching assistant
Stefanie-Grace Sbergio
stefanie.sbergio@mail.utoronto.ca
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Term |
Fall 2024 |
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Lecture time |
Wednesday, 10 am - 12 pm |
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Tutorial time |
Thursday 12 - 1 pm |
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Office hours |
Contact TA or Course Coordinators |
Course details
Enrolment is limited to students in the Pathobiology specialist program.
- Hours: 24L/12T
- Prerequisite: LMP200H1, BCH210H1
- Exclusions: None
- Recommended preparation: None
- Distribution requirements: Science
- Breadth requirement: Living Things and Their Environment (4)
- Enrolment limits: 35 students
Student evaluation
Three in-term midterm tests, scheduled during tutorials (100%)
- Term test 1: 33% - due date 26 September 2024
- Term test 2: 33% - due date 7 November 2024
- Term test 3: 34% - during final exam period
See information on Academic Integrity
Schedule
Lecture topics are subject to change. We will list finalized lecture topics in the official syllabus
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Date |
Topic |
Instructor |
|---|---|---|
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Cancer pathobiology |
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7 September, 2023 |
Introduction to fundamental concepts in cancer biology |
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September 13, 2023 |
Initiation of cancer: predisposition, genetics and environment |
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September 14, 2023 |
Tutorial |
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September 20, 2023 |
Progression of cancer: clonal evolution and tumourigenesis |
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September 21, 2023 |
Tutorial |
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September 27, 2023 |
Invasion of cancer: tumour microenvironment and cell migration |
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September 38, 2023 |
Tutorial |
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|
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Immunopathology |
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October 4, 2023 |
Immunopathological processes during infection |
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October 5, 2023 |
Test 1 (cancer - 34%) |
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October 11, 2023 |
Immunopathology of autoimmunity |
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October 12, 2023 |
Tutorial |
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October 18, 2023 |
Pathobiology of organ transplantation and rejection |
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October 19, 2023 |
Tutorial |
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October 25, 2023 |
Host immune evasion by pathogens |
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October 26, 2023 |
Tutorial |
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|
Inflammation & Atherosclerosis |
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November 1, 2023 |
Overview of inflammation |
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November 2, 2023 |
Tutorial |
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November 8 and 9, 2023 |
Reading Week, no classes |
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November 15, 2023 |
Test 2 (immunopathology 33%) (1.5 hours) Mechanisms of leukocyte emigration I (30 mins) |
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November 16, 2023 |
Mechanisms of leukocyte emigration I |
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November 22, 2023 |
Mechanisms of leukocyte emigration II |
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November 23, 2023 |
Tutorial |
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November 29, 2023 |
Leukocyte trafficking in atherosclerosis |
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November 30, 2023 |
Tutorial |
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December 6, 2023 |
Test 3 (inflammation lectures 25%) |
Recommended reading or text book
None.