LMP450H1 – Organogenesis in Health and Disease

Course description

This course introduces advanced topics in stem cell biology and focuses on the latest developments related to the use of stem cells in the design and generation of organoids and organs for use in research.

We will highlight the use of organogenesis within basic and clinical research settings, with a focus on several human diseases.

This course will build on the third-year course LMP320H1, through which you will have been introduced to stem cell biology within the context of human diseases.

Course coordinators

Dr. Karun Singh

Office address: Krembil Research Institute, 60 Lenard Ave, Rm 7KD-417
karun.singh@uhnresearch.ca

Teaching assistant

Justin Callahan

jd.callahan@mail.utoronto.ca

Term	Fall 2024
Lecture time	Friday 10 am - 12 pm
Tutorial time	Friday 12 - 1 pm
Office hours	Contact TA or Course Coordinators

Course details

Hours: 24L/12T
Prerequisite: LMP320H1, LMP330H1
Exclusions: None
Recommended preparation: None
Distribution requirements: Science
Breadth requirement: Living Things and Their Environment (4)
Enrolment limits: 30 students

Student evaluation

30% - Midterm - due 4 October, 2024

40% - Group oral presentation - This will include preparing a slide deck with group members, oral presentation of the scientific paper, and answering questions (orally).

30% - Final exam

See information on Academic Integrity

Schedule

Lecture topics are subject to change. We will list finalized lecture topics in the official syllabus

Date	Lecture hour 1: 10:10 - 11 am	Lecture hour 2: 11:10 am - 12 pm
September 8, 2023	Introduction to stem cells Dr. Karun Singh	Stem cell paper presented by faculty Dr. Karun Singh
September 15, 2023	Applications employing stem cells Dr. Karun Singh	Stem cell paper presented by faculty Dr. Michael Laflamme
September 22, 2023	Tissue patterning and organ development Dr. Shinichiro Ogawa	Stem cell paper presented by faculty Dr. Shinichiro Ogawa
September 29, 2023	Intestinal organoids Dr. Shinichiro Ogawa	Hepatic and pancreatic organoids Dr. Shinichiro Ogawa
October 6, 2023	Midterm Examination
October 13, 2023	Cerebral organoids and organogenesis Dr. Karun Singh	Cancer organoids Dr. Karun Singh Dr. Shinichiro Ogawa
October 20, 2023	Kidney/lung organoids Dr. Shinichiro Ogawa Dr. Michael Laflamme	Cardiac organoids Dr. Michael Laflamme
October 27, 2023	Organogenesis: engineering organs Dr. Michael Laflamme	Approach to dissecting a manuscript/ In-class journal club prep Dr. Michael Laflamme
November 3, 2023	Immune organoids Guest lecturer Dr. Julien Muffat	In-class journal club prep All faculty
November 10, 2023	Reading Week, no classes
November 17, 2023	Student Oral Presentations All faculty
November 25	Student Oral Presentations All faculty
December 2	Student Oral Presentations All faculty	Course Review All faculty