LMP410H1 - Pathobiology of Neurodegenerative Disease 24L
Course description
Focussing on the molecular basis of neurodegenerative diseases of the central and peripheral nervous systems.
We cover the molecular pathobiology of neurodegenerative diseases, current research developments, and writing research proposals.
You will practice the assembly of a succinct research proposal and query neurodegenerative disease material taught in the course in the mid-term and final exams.
Course coordinator
Toronto Western Hospital: University Health Network (UHN)
399 Bathurst St., Rm 9MC 422, Toronto, Ontario Canada M5T 2S8
Teaching assistant
TBA
|
Term |
Fall 2024 |
|
Class and tutorial details |
Available on Quercus Wednesday 10 am - 12 pm |
|
Last day to drop course |
November 6 (25% of final mark released before November 5) |
|
Office hours |
In-person meetings can be arranged with short notice. |
Course details
- Hours: Approximately 24 hours for lectures, as well as mid-term and final exam
- Prerequisite: BCH311H1/( PSL300H1, PSL301H1)
- Exclusions: none
- Breadth requirement: none
- Enrolment limits: 40 students
Student evaluation
Mid-term: 25% for in-class component (due 16 October, 2024) plus 25% for homework grant proposal (due 25 October, 2024)
Final exam: 50% for neurodegenerative disease material test
See information on Academic Integrity
Schedule
|
Date |
Topic and estimated time spent |
|---|---|
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September 4, 2024 |
Introduction to course and overview |
|
September 11, 2024 |
Prion Diseases How to improve scientific writing in general |
|
September 18, 2024 |
Genetics How to develop an introduction/rationale section for a project proposal |
|
September 25, 2024 |
Nodding Syndrome How to come up with a project title and write a significance section |
|
October 2, 2024 |
Tauopathies How to generate a hypothesis and break a project into 2 - 3 specific aims |
|
October 9, 2024 |
ALS/FTD How to write a concise work plan |
|
October 16, 2024 |
Mid-term (2 hours) |
|
October 23, 2024 |
Imaging and diagnostics |
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November 6, 2024 |
Alzheimer’s disease and therapy |
|
November 13, 2024 |
Degenerative Diseases of the Eye |
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November 20, 2024 |
Neuroanatomy/pathology |
|
November 27, 2024 |
Parkinson’s Disease |
Recommended reading or text book
You are encouraged to familiarize yourself with software packages that automate the management and assembly of bibliographies (e.g., Endnote, Mendeley, Zotero, RefWorks).
The following is a list of useful resources (none of these are essential for this course but they should provide useful information and context):
Free online resources for general information on scientific writing
- Scientific Literacy: Clear as mud (by Jonathan Knight) (source: Nature)
- Scientific Writing (source: Duke University Graduate School)
- Ten Simple Rules for Getting Grants Bourne PE, & Chalupa LM. 2016. PLoS Computational Biology
- Writing in the Sciences. Kristina Sainani. Stanford University. One of several Coursera online training courses related to this subject (several sessions are also available on YouTube)
Books you can purchase:
- The Chicago Guide to Communicating Science. Scott L. Montgomery. Published December 15th, 2002, by University Of Chicago Press. ISBN: 0226534855
- Scientific and Medical Communication. Scott A. Mogull. Published April 8, 2016, by Routledge. ISBN: 1138842559.
- Grant Writing in Higher Education: A Step‐by‐Step Guide. Kenneth T. Hensen. Published 2003 by Allyn & Bacon. ISBN‐13: 978‐0205389193