Ken Craddock
MD, FRCPC, FCCMG
Research Synopsis
Translational research aimed at developing clinically relevant genetic biomarker testing in the pathology laboratory.
Genetics of haematologic neoplasms (lymphomas and leukemias), lung cancers, and other solid tumours, and their diagnostic, prognostic, and predictive associations.
Interpretation and classification of comprehensive genomic profiling data of cancers in the context of their pathologic characteristics.
Recent Publications
Torlakovic E, Albadine R, Bigras G, Boag A, Bojarski A, Cabanero M, Camilleri-Broet S, Cheung C, Couture C, Craddock KJ, Cutz JC, Dhamanaskar P, Fiset PO, Hossain M, Hwang D, Ionescu D, Itani D, Kelly M, Kwan K, Lim HJ, Nielsen S, Qing G, Sekhon H, Spatz A, Waghray R, Wang H, Xu Z, Tsao MS. Canadian Multicenter Project on Standardization of Programmed Death-Ligand 1 Immunohistochemistry 22C3 Laboratory-Developed Tests for Pembrolizumab Therapy in NSCLC. J Thoracic Oncology 2020;15(8):1328-37.
Fiset PO, Labbe C, Young K, Craddock KJ, Smith A, Tanguay J, Pintilie M, Wang R, Torlakovic E, Cheung C, Santos GC, Ko H, Boerner S, Hwang D, Leighl N, Tsao MS. Anaplastic lymphoma kinase 5A4 immunohistochemistry as diagnostic assay in lung cancer: a Canadian reference testing center’s results in population based reflex testing. Cancer 2019;125(22):4043-4051.
Chiu JW, Krzyzanowska MK, Serra S, Knox JJ, Dhani NC, Mackay H, Hedley D, Moore M, Liu G, Burkes RL, Brezden-Masley C, Roehrl MH, Craddock KJ, Tsao MS, Zhang T, Yu C, Kamel-Reid S, Siu LL, Bedard PL, Chen EX. Molecular profiling of patients with advanced colorectal cancer: Princess Margaret Cancer Centre Experience. Clin Colorectal Cancer 2018;17(1):73-79.
Tokar T, Pastrello C, Ramnarine VR, Zhu CQ, Craddock KJ, Pikor LA, Vucic EA, Vary S, Shepherd FA, Tsao MS, Lam WL, Jurisica I. Differentially expressed microRNAs in lung adenocarcinoma invert effects of copy number aberrations of prognostic genes. Oncotarget 2018;9(10):9137-9155.
Khoral P, Atenafu EG, Craddock KJ, Schimmer A, Chang H. Prognostic effect of complex karyotype, monosomal karyotype, and chromosome 17 abnormalities in B-cell acute lymphoblastic leukemia. Clin Lymphoma Myeloma Leuk 2017;17(4):215-219.
Craddock KJ*, Sukhai MA*, Thomas M, Hansen AR, Zhang T, Siu L, Bedard P, Stockley TL, Kamel-Reid S. A classification system for clinical relevance of somatic variants identified in molecular profiling of cancer. Genetics in Medicine 2016;18(2):128-36.
Lerner-Ellis J, Wang M, White S, Lebo MS, and the Canadian Open Genetics Repository Group. Canadian Open Genetics Repository (COGR): a unified clinical genomics database as a community resource for standardizing and sharing genetic interpretations. J Med Genet. 2015;52(7)438-45.
Cutz JC, Craddock KJ, Torlakovic E, et al. Canadian anaplastic lymphoma kinase study: a model for multicenter standardization and optimization of ALK testing in lung cancer. Journal of Thoracic Oncology 2014;9(9):1255-63.
Craddock KJ*, Hosseini N*, Salehi-Rad S, Brennan S, Bailey DJ, Brandwein JM, Porwit A. ETV6/FLT3 fusion in a mixed phenotypic acute leukemia arising in lymph nodes in a patient with myeloproliferative neoplasm with eosinophilia. Journal of Hematopathology. 2014;7:71-77.
Guo RJ, Atenafu E, Craddock KJ, Kim D, Chang H. Allogeneic hematopoietic cell transplantation may alleviate the negative prognostic impact of monosomal and complex karyotypes on patients with acute myeloid leukemia. Biol Blood Marrow Transplant. 2014;20(5):690-5.
Craddock KJ, Ludkovski O, Sykes J, Pintilie M, Tsao MS. Prognostic value of fibroblast growth factor receptor 1 gene locus amplification in resected lung squamous cell carcinoma. Journal of Thoracic Oncology. 2013;8(11):1371-1377.
Craddock KJ, Jiang A, Brandwein JM, Chang H. CD13 expression is an independent adverse prognostic factor in adults with Philadelphia chromosome negative B cell acute lymphoblastic leukemia. Leukemia Research. 2013;37(7):759-764.
Craddock KJ, Tam S, Zhu CQ, Tsao MS. Genomic Pathology of Lung Cancer. In: Pfeffer U, ed. Cancer Genomics: Molecular Classification, Prognosis, and Response Prediction. New York, NY: Springer; 2013.
Craddock KJ, Lam WL, Tsao MS. Applications of array-CGH for lung cancer. In: Banerjee D & Shah SP, eds. Array Comparative Genomic Hybridization: Protocols and Applications. New York, NY: Humana Press; 2013.
Craddock KJ*, John T*, Yanagawa N*, Kohler D*, Pintilie M, Sykes J, Li M, Panchal D, Shepherd FA, Tsao MS. Characterization of human lymphomas developing from lung cancer primary tumour xenograft implantations. Journal of Thoracic Oncology. 2012;7:1101-1108.