Lianna Kyriakopoulou

Dr. Kyriakopoulou is a clinical molecular geneticist and a clinical biochemist. She is currently, a director in the Genome Diagnostics Laboratory at the Hospital for Sick Children.

Her research interests are in the areas of genetic metabolic disorders, rare genetic disorders and cancer. Her translational research focuses on the development of functional genomic platforms for the clinical laboratory using high-throughput methodologies.

Selected Publications

Villani A, Davidson S, Kanwar N,, Lo W, Yisu Li, Cohen-Gogo S, Fuligni F, Edward LM, Light N, Harripaul R, Waldman L, Gallinger B, Comitani C, Layeghifard M, Brunga L, Reid Hayes, Anderson ND, Ramani AK, Yuki KE, S Blay , Brittney Johnstone B, Inglese C, Hammad R, Catherine Goudie C, Shuen A, Wasserman JD, Venier RE, Eliou M, Lorenti M, Ryan CA, Braga M4, Gloven-Brown M4, Han J4, Maria Montero M, Famida Spatare F, Whitlock J, Scherer S, Chun K, Somerville M, Hawkins C, Abdelhaleem M, Vijay Ramaswamy V, Somers RG, Kyriakopoulou L, Hitzler, Shago M, Morgenstern D,Tabori U, Meyn S, Irwin M, Malkin D,Adam Shlien. The clinical utility of genomics in childhood cancer extends beyond targetable mutations. Nature Cancer.

Sneha Tandon, Jack Bartram , Lianna Kyriakopoulou , Nisha Kanwar , Winnie Lo, Scott Davidson , Angela Punnett , Adam Shlien , Johann Hitzler, David Malkin, Anita Villani, Oussama Abla. Failure of Romidepsin to Treat Relapsed/Refractory Peripheral T-Cell Lymphoma in Children: A Singlecenter Experience. J Pediatr Hematol Oncol. 2021 Jul 1;43(5)

Abdulhakim Jilani, Diana Matviychuk, MSc, Susan Blaser, MD, Sarah Dyack, MD, Jean Mathieu, MD, MSc, Asuri Narayan Prasad, MD, Chitra Prasad, MD, Lianna Kyriakopoulou, PhD, Saadet Mercimek Andrews, MD, PhD. High diagnostic yield of direct Sanger sequencing in the diagnosis of neuronal ceroid lipofuscinoses. JIMD Reports 2019 Sep 3;50(1):20-30

Eckford PDW, McCormack J, Munsie L, He G, Stanojevic S, Pereira SL, Ho K, Avolio J, Bartlett C, Yang JY, Wong AP, Wellhauser L, Huan LJ, Jiang JX, Ouyang H, Du K, Klingel M, Kyriakopoulou L, Gonska T, Moraes TJ, Strug LJ, Rossant J, Ratjen F, Bear CE. J Cyst Fibros. 2019 Jan;18(1):35-43. doi: 10.1016/j.jcf.2018.03.013. The CF Canada-Sick Kids Program in individual CF therapy: A resource for the advancement of personalized medicine in CF.

Al Teneiji A, Bruun TU, Sidky S, Cordeiro D, Cohn RD, Mendoza-Londono R, Moharir M, Raiman J, Siriwardena K, Kyriakopoulou L, Mercimek-Mahmutoglu S. Phenotypic and genotypic spectrum of congenital disorders of glycosylation type I and type II. Mol Genet Metab. 2017 Jan 3. pii: S1096- 7192(16)30393-6.          

Honours and awards

LMP Sustained Excellence Education Award, 2024

LMP Teaching Award for Undergraduate Education, 2019.