Mary Shago
PhD, FCCMG
Research Synopsis
Our laboratory combines expertise in cytogenetic technique, classical G-band, spectral karyotyping, chromosome instability syndrome, microarray and FISH analyses, leading to a number of collaborative studies on acute lymphoblastic and acute myeloid leukemias (ALL and AML), pediatric solid tumours, and ongoing work in specific subtypes of pediatric ALL.
Recent Publications
Goh E, Perez I, Ruiz P, Agatep R, Goobie S, Yoon G, Shago M, Sgro M, Chitayat D, Dror Y, Walz K, and Mendoza-Londono R. Definition of a critical genetic interval related to kidney abnormalities in the Potocki-Lupski syndrome. Am J Med Genet. Jul;158A(7):1579-88, 2012.
Connor A, Perez-Ordoñez B, Shago M, Skálová A, Weinreb I. Mammary Analog Secretory Carcinoma of Salivary Gland Origin With the ETV6 Gene Rearrangement by FISH: Expanded Morphologic and Immunohistochemical Spectrum of a Recently Described Entity. Am J Surg Pathol. Jan;36(1):27-34, 2012.
Ghai SJ, Shago M, Shroff M and Yoon G. Cockayne syndrome caused by paternally inherited deletion of 10q11.2 and a frameshift mutation of ERCC6. Eur J Med Genet 2011 54(3):272-6.
Shlien A, Baskin B, Achatz MI, Stavropoulos DJ, Nichols KE, Hudgins L, Morel CF, Adam MP, Zhukova N, Rotin L, Novokmet A, Druker H, Shago M, Ray PN, Hainaut P, and Malkin D. A common molecular mechanism underlies two phenotypically distinct 17p13.1 microdeletion syndromes. Am J Hum Genet. 87(5):631-42, 2010.
Goobie S, Knijnenburg J, FitzPatrick D, Sharkey FH, Lionel AC, Marshall CR, Azam T, Shago M, Chong K, Mendoza-Londono R, den Hollander NS, Ruivenkamp C, Maher E,Tanke HJ, Szuhai K, Wintle RF, Scherer SW. Molecular and clinical characterization of de novo and familial cases with microduplication 3q29: guidelines for copy number variation case reporting. Cytogenet. Genome Res.,123(1-4):65-78, 2008.
Marshall CR, Noor A, Vincent JB, Lionel AC, Feuk L, Skaug J, Shago M, Moessner R, Pinto D, Ren Y, Thiruvahindrapduram B, Fiebig A, Schreiber S, Friedman J, Ketelaars CE, Vos YJ, Ficicioglu C, Kirkpatrick S, Nicolson R, Sloman L, Summers A, Gibbons CA, Teebi A, Chitayat D, Weksberg R, Thompson A, Vardy C, Crosbie V, Luscombe S, Baatjes R, Zwaigenbaum L, Roberts W, Fernandez B, Szatmari P, and Scherer SW. Structural variation of chromosomes in autism spectrum disorder. Am J Hum Genet 82(2):477-88, 2008.
Kim S, Shago M, Kaustov L, Boutros P, Sheng Y, Trentin G, Barsite-Lovejoy D, Clendening JW, Mao D, Kay R, Jurisica I, Arrowsmith C, and Penn LZ. CUL7 is a novel oncogene that cooperates with Myc in transformation. Cancer Research, 67(20):9616-9622, 2007.
Abla O, Dror Y and Shago M. Translocation (X;10) in a child with therapy-related acute myeloid leukemia following chemotherapy for Ewing’s sarcoma. Cancer Genet Cytogenet 178(2):168-9, 2007.
Levy S, Sutton G, Ng PC, Feuk L, Halpern AL, Walenz BP, Axelrod N, Huang J, Kirkness EF, Denisov G, Lin Y, Macdonald JR, Pang AW, Shago M, Stockwell TB, Tsiamouri A, Bafna V, Bansal V, Kravitz SA, Busam DA, Beeson KY, McIntosh TC, Remington KA, Abril JF, Gill J, Borman J, Rogers YH, Frazier ME, Scherer SW, Strausberg RL, and Venter JC. The diploid genome sequence of an individual human. PLoS Biol. Sep 4;5(10):e254, 2007.
Abdelhaleem M, Shago M, Beimnet K, Sayeh E, Bartakke S, and Weitzman S. Childhood acute myeloid leukemia with hemophagocytosis by the blasts and inv(8)(p11q13) with MOZ-TIF2 fusion transcipts. J. Pediatr Hematol Oncol. 29(9): 643-5, 2007.
Abdelhaleem M, Beimnet K, Kirby-Allen M, Naqvi A, Hitzler J, and Shago M. High incidence of CALM-AF10 fusion and the identification of a novel transcript in acute megakaryoblastic leukemia in children without Down syndrome. Leukemia. 2007 Feb 21(2)352-3, 2006.