Nadine Shehata

Nadine Shehata is an adult hematologist with an interest in Maternal Fetal Hematology/Transfusion Medicine.

She is the medical director of the transfusion medicine laboratory at Mount Sinai Hospital.

Research Synopsis

Transfusion medicine and cardiovascular surgery

We are conducting a multicenter pilot randomized controlled trial funded by CIHR to address the optimum hemoglobin concentration for red cell transfusion in patients undergoing cardiac surgery.

The pilot study will form the basis of a large definitive randomized controlled trial.

We are also interested in optimizing platelet utilization in this population as there is a need to define the indications for transfusion to avoid the adverse events of transfusion.

Transfusion medicine and maternal fetal medicine

We are establishing databases for patients with:

1. red cell alloimmunization during pregnancy to address the correlation between antibody titres and clinical outcomes and to investigate alloantibody formation
2. alloimmunization to platelet antigens to characterize patients with neonatal alloimmune thrombocytopenia.

We are also interested in looking at maternal screening for these antigens using fetal gentoyping from maternal plasma for patients alloimmunized to red cell and platelet antigens.

Hematological disorders in pregancy

We are establishing a prospective database of all hematological disorders in pregnancy.

All patients with hematological disorders e.g. thrombosis, immune thrombocytopenia and hemoglobinopathies will be entered into the database to allow for:

1. assessment of therapeutic measures
2. analysis of adverse outcomes
3. research initiatives.

Evidence based practice guideline

We are establishing an international collaboration to develop evidence based practice guidelines for transfusion medicine.

This international initiative welcomes recommendations for guideline topics.

Selected Publications

Shehata N, Burns LA, Nathan H, Hebert P, Hare GMT, Fergusson D, Mazer D. A Randomized Controlled Pilot Study of Adherence to Transfusion Strategies in Cardiac Surgery. Transfusion. 2012 Jan;52(1):91-99. Co-Principal Author.

Hare GMT, Mu A, Romaschin A, Shehata N, Beattie S, Mazer CD. Plasma Methemoglobin as a Potential Biomarker of Anemic Stress in Humans. Canadian Journal of Anesthesia. 2012 Apr;59(4):348-56. Coauthor or Collaborator.

Shehata N, Denomme G, Hannach B, Banning N, Freedman J. Mass-scale High-throughput Multiplex PCR for HPA Single-Nucleotide Polymorphisms Screening of Apheresis Platelet Donors. Transfusion. 2011 Sep;51(9):2028-33. Co-Principal Author.

Appointments

Medical Director, Transfusion Medicine Laboratory, Mount Sinai Hospital