Rola Saleeb

Dr. Saleeb had her Medical degree from the Kasr Al-Einy Faculty of Medicine, Cairo University.

She completed a combined Anatomical Pathology postgraduate training/PhD training at University of Toronto.

She has also completed the one-year Transformative Pathology molecular fellowship granted by the Ontario Institute of Cancer Research.

Dr. Saleeb’s research focus is Genitourinary Pathology and Kidney cancer.

Research Synopsis

My research focus is translational research in the fields of Molecular Pathology and Genitourinary pathology.

I believe in the importance of integrating the tumor’s morphology with its molecular makeup to define and determine its characteristics.

My doctorate research was focused on studying Papillary Renal Cell Carcinoma, for which we have proposed a combined molecular and morphological classification, (“biological classification”) that would better stratify patients from prognostic and predictive aspects.

Selected Publications

Saleeb, Rola M., et al. "Integrated Molecular Analysis of Papillary Renal Cell Carcinoma and Precursor Lesions Unfolds Evolutionary Process from Kidney Progenitor-Like Cells." The American Journal of Pathology (2019).

Saleeb, Rola M., Mina Farag, Zsuzsanna Lichner, Fadi Brimo, Jenni Bartlett, Georg Bjarnason, Antonio Finelli, Fabio Rontondo, Michelle R. Downes, and George M. Yousef. "Modulating ATP Binding Cassette (ABC) Transporters in Papillary Renal Cell Carcinoma Type 2 Enhances its Response to Targeted Molecular Therapy." Molecular oncology (2018)

Lichner, Z., Saleeb, R., Butz, H., Ding, Q., Nofech-Mozes, R., Riad, S., ... & Yousef, G. M. (2018). Sunitinib induces early histomolecular changes in a subset of renal cancer cells that contribute to resistance. The FASEB Journal, fj-201800596R.

Di Meo, Ashley, Rola Saleeb, Samantha J. Wala, Heba W. Khella, Qiang Ding, Haiyan Zhai, Kalra Krishan et al. "A miRNA-based classification of renal cell carcinoma subtypes by PCR and in situ hybridization." Oncotarget 9, no. 2 (2018): 2092.

Saleeb, Rola M., Fadi Brimo, Mina Farag, Alexis Rompré-Brodeur, Fabio Rotondo, Vidya Beharry, Samantha Wala et al. "Toward Biological Subtyping of Papillary Renal Cell Carcinoma With Clinical Implications Through Histologic, Immunohistochemical, and Molecular Analysis." The American journal of surgical pathology 41, no. 12 (2017): 1618-1629.

Saleeb RM, Srigley JR, Sweet J, et al. “Melanotic MiT family translocation neoplasms: Expanding the clinical and molecular spectrum of this unique entity of tumors”. Pathol - Res Pract. 2017;in press

Saleeb, Rola M., Pamela Plant, Eriny Tawedrous, Adriana Krizova, Fadi Brimo, Andrew J. Evans, Samantha Jane Wala et al. "Integrated Phenotypic/Genotypic Analysis of Papillary Renal Cell Carcinoma Subtypes: Identification of Prognostic Markers, Cancer-related Pathways, and Implications for Therapy." European Urology Focus (2016).

Saleeb, Rola, and Catherine J. Streutker. "Glomus tumor of the rectum: A case report." Human Pathology: Case Reports (2016).

Saleeb, R., H. Faragalla, G. M. Yousef, R. Stewart, and C. J. Streutker. "Malignancies in a renal transplant population: The St. Michael's Hospital experience." Urology annals 8, no. 2 (2016): 163.

Shao, Tiffany, Peter Yousef, Irina Shipilova, Rola Saleeb, Jason Y. Lee, and Adriana Krizova. "Clear cell papillary renal cell carcinoma as part of histologically discordant multifocal renal cell carcinoma: A case report and review of literature." Pathology-Research and Practice 212, no. 3 (2016): 229-233.

Wala, Samantha Jane, Jason Raj Karamchandani, Rola Saleeb, Andrew Evans, Qiang Ding, Rania Ibrahim, Michael Jewett et al. "An integrated genomic analysis of papillary renal cell carcinoma type 1 uncovers the role of focal adhesion and extracellular matrix pathways." Molecular oncology 9, no. 8 (2015): 1667-1677.

Saleeb, R., H. Faragalla, G. M. Yousef, R. Stewart, and C. J. Streutker. "Malignancies arising in allograft kidneys, with a first reported translocation RCC post-transplantation: A case series". Pathology-Research and Practice 211, no. 8 (2015): 584-587.