LMP363H1 - Principles of Pathobiology 24L

Course description

The objective of this course is to familiarize you with the principles underlying the ways in which living organisms, in particular mammalian organisms, and their contained organs, tissues and cells, respond and react to disturbances in the environment (exogenous and endogenous) that may lead to disease.

The emphasis in this course will be mainly descriptive, in that the orientation will be the patterns of responses and their consequences to the host. However, where applicable, we will explore biochemical and molecular mechanisms.

We will include cell and tissue injury, repair, inflammation, immune responses, selected toxic agents, neoplasia and a few examples of selected responses of specific organ systems to toxic agents.

Course coordinator

Dr. Jessie Wu

Office address: St. Michael’s Hospital, 30 Bond St.

Jessie.Wu@unityhealth.to

Teaching assistant

TBA

Term	Fall 2024
Class time	Tuesday, 1 - 3 pm
Office hours	Appointments scheduled with students as needed by e-mail

Course details

Hours: 24L
Prerequisite: BIO230H1, CHM247H1/ CHM249H1
Exclusions: LMP300Y1
Distribution requirements: Science
Breadth requirement: Living Things and Their Environment (4)
Enrolment limits: 142 students

Student evaluation

Mid-term test: 40%

Final exam: 60%

See information on Academic Integrity

Schedule - Fall 2024

Dates	Topic
September 12	Introduction Response of the Cell and Tissue to Injury	Dr. Jessie Wu Dr. Sasan Zandi
September 19	Response of the Cell and Tissue to Injury	Dr. Cotton
September 26	Cell Injury and Cell Death – Mechanisms Apoptosis	Dr. Hahn
October 3	Acute Inflammation and Innate Immune Response	Dr. Lee
October 10	Chronic Inflammation and Adaptive Immune Response	Dr. Lee
October 17	Immunopathology	Dr. Lee
October 24	Mid-term test - 1 hour Introduction to Neoplasia	Dr. Manduch
October 31	Inherited predispositions to cancer Cancers associated with infectious agents	Dr. Ju-Yoon Yoon Dr. Hala Faragalla Dr. Wu
November 6 - 10	Reading week, no classes
November 14	Responses of the Brain Responses of the Myocardium	Dr. Julia Keith Dr. Jagdish Butany
November 21	Responses of the Respiratory Tract (virtual) Responses of the Gastrointestinal Tract	Dr. Wee Dr. Sara Hafezi Bakhtiari
November 28	Pathobiology of Selected Diseases in Autopsy Pathology Pathobiology of Forensic Pathology	Dr. Magdaleni Bellis Dr. Patrick Kim
December 5	Responses of the Genitourinary Tract	Dr. Rola Saleeb
TBD	Final Exam