Case of the Month: November 2023

Clinical history

A 12-year-old patient presents to their family physician with a large abdominal mass as well as decrease in appetite and weight loss.  The patient has no history of fever or hematuria.  CT imaging demonstrated near complete replacement of the right kidney by tumour (19.8cm) with direct extension into the right adrenal gland and liver.  Two separate 12 cm masses were also identified within the liver.  Laboratory studies demonstrated normal HVA/VMA, AFP, HCG, INR, PTT

Questions:

  • Based on the clinical information provided, what is your differential diagnosis for a kidney mass in a 12-year-old child?
  • What tumours are associated with the following biochemical markers:
    • HVA/VMA
    • AFP
    • HCG
  • Review the two H&E images below.  What is your new differential diagnosis?

How to participate

Take a look at the H&E images.

Anyone is welcome to try to solve the puzzle by commenting on the related post on our Instagram.

If you are a medical student at the University of Toronto, you can also:

If you do, you are in for a chance to win a $100 gift card! (UofT Med students only).

If you are a current medical student at U of T, you can register to join the November case of the month lecture online or in person and have a chance to win a $100 gift card!

You can also join the Special Interest Group in Laboratory Medicine to learn more about Laboratory Medicine.