Eugene Hsieh

Dr. Hsieh graduated from medical school at McGill University in 1993, and completed his residency in anatomic pathology at the University of Toronto in 1998. After completing a fellowship in gastrointestinal and molecular pathology at the Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, he began his career as a staff pathologist at Sunnybrook and Women’s College Health Sciences Centre in 1999.

Dr. Hsieh led the gastrointestinal and hepatopancreaticobiliary pathology service from 2003 to 2010 and from 2014 to 2019. An expert GI & HPB pathologist, Dr. Hsieh established Sunnybrook as a regional referral centre for diagnostic consultations and as a leading centre for gastrointestinal biomarker testing in the province - as one of the first centres to implement immunohistochemical and molecular screening for Lynch syndrome in colorectal cancers, and one of two Cancer Care Ontario reference centres for gastric HER2/neu testing.

Research Synopsis

My main focus is on novel biomarkers and potential immune targets in gastrointestinal and hepatopancreaticobiliary cancer.

Recent Publications

Selected list of publications:

Mendez LC, Hsieh E, Earle CC, Wong S. Synchronous anal canal carcinoma in a heterosexual couple. BMC Cancer. 2018 Sep 10;18(1):884.

Cheung HMC, Karanicolas PJ, Hsieh E, Coburn N, Maraj T, Kim JK, Elhakim H, Haider MA, Law C, Milot L. Late gadolinium enhancement of colorectal liver metastases post-chemotherapy is associated with tumour fibrosis and overall survival post-hepatectomy. Eur Radiol. 2018 Aug;28(8): 3505-3512.

Sameer Shivji, Elaine Yong, Teresa M Petrella, Eugene T Hsieh. Nivolumab-Induced Collagenous Colitis: A Case Report. Canadian Journal of Pathology: 2018 10(4): 51-55.

Bordman Z, Cohen E, Hsieh E, Cohen LB. Anorectal malignant melanoma in a patient presenting with prolapsing hemorrhoids. Gastrointestinal Endoscopy. 2015 Aug;82(2):417-8.

Tao Wang, Yutaka Amemiya, Pauline Henry, Arun Seth, Wedad Hanna, Eugene T. Hsieh. Multiplex Ligation-dependent Probe Amplification Can Clarify HER2 Status in Gastric Cancers with “Polysomy 17”. Journal of Cancer. 2015 Feb 26;6(5):403-408. J Cancer 2015; 6(5):403-408.

Tinmouth J, Henry P, Hsieh E, Baxter NN, Hilsden RJ, Elizabeth McGregor S, Paszat LF, Ruco A, Saskin R, Schell AJ, Torlakovic EE, Rabeneck L. Sessile Serrated Polyps at Screening Colonoscopy: Have They Been Under Diagnosed? Am J Gastroenterol. 2014 Jul 8.

Linda Rabeneck; Lawrence F. Paszat; Robert J. Hilsden; S. Elizabeth McGregor; Eugene Hsieh; Jill Tinmouth, PhD, Nancy N Baxter; Refik Saskin; Arlinda Ruco; David Stock. Advanced Proximal Neoplasia of the Colon in Average Risk Adults. Gastrointestinal Endoscopy. 2014 Mar 27;80(4):660-667.

Tao Wang, MD; Eugene T Hsieh, MDCM; Pauline Henry, MD, PhD; Wedad Hanna, MBCh, MD; Catherine J Streutker, MD, MSc; Andrea Grin, MD. Matched biopsy and resection specimens of gastric and gastroesophageal adenocarcinoma show high concordance in HER2 Status. Human Pathology. 2014 Jan 8. Hum Pathol. 2014 May;45(5):970-5.

Yogeswaran K, Chen G, Cohen L, Cooper MA, Yong E, Hsieh E, Rowsell C, Saibil F, Tinmouth J. How well is Helicobacter pylori treated in usual practice? Can J Gastroenterol. 2011 Oct; 25(10): 543-6.

Shapero TF, Hoover J, Paszat LF, Burgis E, Hsieh E, Rothwell DM, Rabeneck L. Colorectal cancer screening with nurse-performed flexible sigmoidoscopy: results from a Canadian community-based program. Gastrointest Endosc. 2007 Apr;65(4):640-5.

Tinmouth J, Rachlis A, Wesson T, Hsieh, E. Lymphogranuloma venereum in North America: case reports and an update for gastroenterologists. Clin Gastroenterol Hepatol. 2006 Apr; 4(4): 469-73.

Ollila S, Fitzpatrick R, Sarantaus L, Kariola R, Ambus I, Velsher L, Hsieh E, Andersen MK, Raevaara TE, Gerdes AM, Mangold E, Peltomaki P, Lynch HT, Nystrom M. The importance of functional testing in the genetic assessment of Muir-Torre syndrome, a clinical subphenotype of HNPCC. Int J Oncol. 2006 Jan; 28(1): 149-53.

Wright FC, Law CH, Last LD, Ritacco R, Kumar D, Hsieh ET, Khalifa M, Smith AJ. Barriers to optimal assessment of lymph nodes in colorectal cancer specimens. Am J Clin Pathol. 2004 May; 1221(5): 663-70.

Gryfe R, Kim H, Hsieh ET, Holowaty EJ, Bull S, Redston M, Gallinger S. Tumor Microsatellite Instability and Patient Survival in a Population-Based Series of Young Colorectal Cancer Patients. N Engl J Med. 2000 Jan 13; 342(2): 69-77.

Marcus VA, Madlensky L, Gryfe R, Kim H, So K, Millar A, Temple LK, Hsieh E, Hiruki T, Narod S, Bapat BV, Gallinger S, Redston M. Immunohistochemistry for hMLH1 and hMSH2: a practical test for DNA mismatch repair deficient tumors. Am J Surg Pathol. 1999 Oct; 23(10): 1248-55.