Julius Hreinsson
PhD
BSc in Biology from the University of Iceland 1987. PhD in Medical Science from the Karolinska Institute, Stockholm 2003. Title of thesis: Preservation of fertility through cryopreservation and in vitro maturation of human ovarian follicles and oocytes. MSc in Business Management from Uppsala University in 2015. ESHRE certified Senior Clinical Embryologist in 2008.
Worked as a clinical embryologist since 1991 and have held Laboratory Director positions at Uppsala University Hospital and the Karolinska University Hospital in Stockholm since 2002 as well as other management and R/D positions.
Active in professional societies such as ESHRE, the Nordic Fertility Society (NFS) and the Swedish Society for Reproductive Medicine (SSRM). Held board member positions in NFS and SSRM (cashier) and chaired the SSRM between 2017-2019.
Research Synopsis
My research has mainly focused on culture conditions for human embryos and on cryopreservation techniques. We have studied the effect of various growth factors and culture media supplements on human embryo development in vitro to identify viability markers for human embryos. Several of the studies utilized time lapse technology to assess embryo development.
I was involved in the first live birth after ovarian tissue cryopreservation in Sweden and have worked with human ovarian follicle culture and studied cryopreservarion techniques. Analysis of follicle development and competence continues to be a part of my research interests.
Selected Publications
Jensen PL, Beck HC, Petersen J, Hreinsson J, Wånggren K, Laursen SB, Sørensen PD, Christensen ST, Andersen CY. Proteomic Analysis of Human Blastocoel Fluid and Blastocyst Cells. Stem Cells Dev. 2013; 22(7): 1126-1135.
Hambiliki F, Hanrieder J, Bergquist J, Hreinsson J, Stavreus-Evers A, Wånggren K. Glycoprotein 130 promotes human blastocyst development in vitro. Fertil Steril. 2013. 99(6): 1592-1599.
Rodriguez-Wallberg KA, Karlström PO, Rezapour M, Castellanos E, Hreinsson J, Rasmussen C, Sheikhi M, Ouvrier B, Bozóky B, Olofsson JI, Lundqvist M, Hovatta O. Full-term newborn after repeated ovarian tissue transplants in a patient treated for Ewing sarcoma by sterilizing pelvic irradiation and chemotherapy. Acta Obstet Gynecol Scand. 2015. 94(3): 324-328.
Triin Pärn, Raúl Grau Ruiz, Theodora Kunovac Kallak, Jonatan Ruiz, Eva Davey, Julius Hreinsson, Kjell Wånggren, Andres Salumets, Michael Sjöström, Anneli Stavreus-Evers, Francisco B Ortega, Signe Altmä. Physical activity, fatness, educational level and snuff consumption as determinants of semen quality: findings of the ActiART study. Reprod Biomed Online. 2015. 31(1): 108-119.
Kovačič B, Plas C, Woodward BJ, Verheyen G, Prados FJ, Hreinsson J, De los Santos MJ, Magli MC, Lundin K, Plancha CE. The educational and professional status of clinical embryology and clinical embryologists in Europe. Hum Reprod. 2015. 30(8): 1755-1762.
Kushnir MM, Naessén T, Wanggren K, Hreinsson J, Rockwood AL, Meikle AW, Bergquist J. 2016. Exploratory study of the association of steroid profiles in stimulated ovarian follicular fluid with outcomes of IVF treatment. J Steroid Biochem Mol Biol. 162:126-133.
Lindgren KE, Hreinsson J, Helmestam M, Wånggren K, Poromaa IS, Kårehed K, Åkerud H. Histidine-rich glycoprotein derived peptides affect endometrial angiogenesis in vitro but has no effect on embryo development. Syst Biol Reprod Med. 2016 Jun;62(3):192-200.
Kaihola H, Yaldir FG, Hreinsson J, Hörnaeus K, Bergquist J, Olivier JD, Åkerud H, Sundström-Poromaa I. 2016. Effects of Fluoxetine on Human Embryo Development. Front Cell Neurosci. 10:160. doi: 10.3389/fncel.2016.00160. eCollection 2016.
Hreinsson J, Hardarson T, Lind AK, Nilsson S, Westlander G. 2016. Perspectives on results from cryopreservation/thawing cycles. Hum Reprod. 31(12):2894.
Cesta CE, Johansson ALV, Hreinsson J, Rodriguez-Wallberg KA, Olofsson JI, Holte J, Wramsby H, Wramsby M, Cnattingius S, Skalkidou A, Nyman Iliadou A. 2018. A prospective investigation of perceived stress, infertility-related stress, and cortisol levels in women undergoing in vitro fertilization: influence on embryo quality and clinical pregnancy rate. Acta Obstet Gynecol Scand. 97(3):258-268.
Lindgren KE, Gülen Yaldir F, Hreinsson J, Holte J, Kårehed K, Sundström-Poromaa I, Kaihola H & Åkerud H. (2018). Differences in secretome in culture media when comparing blastocysts and arrested embryos using multiplex proximity assay. Upsala Journal of Medical Sciences, DOI: 10.1080/03009734.2018.1490830.